Roundup of Bosch Packaging Technology Featured in our 2019 Posts

Read more about the technology featured on our blog in 2019!

HQL 6000-8000

The new HQL 6000-8000 depyrogenation tunnels offer a modular concept with improved accessibility and maintenance while substantially reducing energy consumption. A multi-purpose filling line delivered from the Minneapolis plant this fall included an HQL 8560S, the longest tunnel Bosch has manufactured to date. The massive tunnel consisted of five sterilization zones and six sterilizable cooling zones to process 14 different glass vial sizes ranging from 2 to 100 mL, all at high speed.



FXS 5100

The FXS 5100 filling and closing machine is specifically designed for the processing of pre-sterilized, nested syringes such as SCF™. It was developed to meet the latest pharmaceutical industry requirements with special attention to the needs of the end user. The very compact design reduces expensive sterile area space – whether this is within a conventional clean room or within an isolator system. Additionally, the FXS 5100 has been designed to be serviced exclusively from one side, reducing the time and effort required for maintenance and minimizing the space required for installation by allowing the unit to be wall-mounted, with no rear access required.


Combi Filling Station

The combi filling station is a highly flexible filling platform providing the ability to use multiple filling technologies and dosing units on a single pharmaceutical liquid filling machine. The filling station is interchangeable with multiple individual filling units (peristaltic pumps, time pressure filling, rotary piston pumps, and rolling diaphragm pumps) to ensure a compatible filling process specific to each product without compromising on accuracy. The footprint remains the same as a regular filling station and no filling trolley is needed for additional filling units.



Xelum, Bosch’s platform for continuous production of oral solid dosage (OSD), combines dosing, mixing, granulating and tableting in a continuous process to provide quality, efficiency, flexibility and speed to market. Advantages include shorter development times with less API consumption; a faster and easier transfer from development to production, without the need for scale-up, which is supported with automated DoE functions; and more flexible batch sizes, with precise dosing down to even the smallest amounts of API. Quality assurance is integrated into the process with the use of intelligent sensors. All ongoing processes can be recorded inline, allowing for control of the quality characteristics throughout any stage of production. To further enhance quality control, all ingredients can be easily traced back through the system thanks to the controlled product flow.


Bosch’s patented Automated Process Development (APD) technology platform, combining systematic planning (DoE) with an automated test setup, allows users to perform more experiments in less time. APD provides an efficient and fast determination of the interaction between Critical Material Attributes, Critical Process Parameters, and Critical Quality Attributes. Optimum process parameters and robust production can be determined systematically and the enhanced process understanding and higher product capability leads to better product quality. It’s an investment in the process development phase with a large benefit in commercial manufacturing. Automated adjustments and monitoring guarantee less time and material consumption for broad parameter screening.

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