Join Syntegon at the 2021 Virtual Pharma Expo series event, focused on Oral Solid Dose Manufacturing. On Wednesday, May 5 at 9:30am EDT, Head of Pharma Service and Senior Scientist/Pharmacist Marc Michaelis will be presenting on Continuous Manufacturing. Learn about the benefits of moving from batch production to a continuous process.
Learn more about the event, and register for free here.
Developing an oral solid dosage (OSD) product is not easy; timelines are long, financial risks are considerable and challenges are many. Consequently, significant incentive exists to find efficiencies and streamline the product development process wherever possible. However, one aspect of the pharma development process remains unchanged. Regulatory agencies are unwavering in their demand for evidence that your manufacturing process is stable and the design space well defined; …more
Developing and manufacturing hard-shell capsules with low fill-weights can be an especially challenging task. However, recent innovations provide the tools to make the job of manufacturing such products much easier, while also providing assurance that the capsules you make meet your stringent quality requirements. Whether you need to fill just API into capsules for clinical trials, need to manufacture a low-fill capsule product for dry powder inhalation, or simply have a product formulation that requires low fill-weight, the tools available today can make the job much simpler. …more
COVID-19 is currently challenging our technical professionals in terms of traveling for set-ups and the commissioning of the delivered equipment to our customers worldwide. However, our customers are also suffering from travel restrictions, which make it difficult to carry out a joint Factory Acceptance Tests (FAT) on the manufacturer’s site. A FAT is a process to approve that the equipment aligns with the specifications made for design and functions, before it is dispatched to our customers.
Fluid bed processing has long been used in the Pharmaceutical, Nutraceutical, and Chemical industries as a way to enhance the characteristics of powders, dry products, or apply an active compound or functional coating to the surface of particles or beads, with the objective of controlling release of the product. …more
The pharmaceutical and nutraceutical industries are constantly looking for ways to develop robust and efficient processes across their oral solid dosage (OSD) portfolios. Producing a quality tablet or capsule should start much earlier than when the tablet press or capsule hopper is filled with powder or granules. …more
Syntegon Technology may not be a household name to many people, but if you have worked in oral solid dosage manufacturing for any length of time, you are likely very familiar with our capsule filling machines. That’s because just over one year ago Bosch Packaging Technology, a name synonymous with capsule filling, became Syntegon Technology, a fully independent provider of processing equipment for the pharmaceutical, nutraceutical and food industries. And in our first year as an independent company …more
Developing a capsule or tablet product is fraught with hurdles, both financial and technical. Traditional process development generally involves what seems like an endless cycle of batch manufacture, followed by testing/characterization, followed by more batch manufacture and even more testing. Execution of just one simple Design of Experiments (DOE) could easily take several days, if not weeks, only to be followed by additional batches. …more
Taking a look back at 2020, everyone will most likely agree we have experienced many new ways to conduct business both personally and professionally. For Syntegon Technology, 2020 was officially the first year we conducted business as a separate and independent entity from what we were formerly known as, which was Bosch Packaging Technology. Syntegon Technology became the new name and face for a leading provider of processing and packaging solutions for the food and pharmaceutical industries. Syntegon has …more
Scale it up quicker and do it more efficiently (i.e. less cost). If you work in pharmaceutical development, you are likely familiar with this mantra. While regulatory hurdles for drug developers seemingly increase by the day, product development budgets don’t seem to follow the same upward trajectory. In fact, it seems that development and manufacturing personnel, more often than not, are asked to do more with less. …more
