Solid Dosage

Capsylon Capsule Fillers: The Benchmark for Cost-Effective Capsule Filling

For decades, Syntegon Pharma Technology has set the standard in capsule filling technology for the Pharmaceutical industry. Pharma manufacturing experts seeking innovation, durability and maximum filling flexibility have intuitively turned to the Syntegon line of GKF capsule fillers. With a variety of filling options including powder-fill, pellet-fill, tablets-in-capsule, or any variety of filling combinations, the GKF line of capsule fillers can tackle any capsule filling challenge thrown at them.

But, what if your capsule filling needs are more simple? …more

SolidLab 1 – Syntegon’s innovative tabletop fluid bed system

Syntegon is excited to announce that we will be live and in-person for the AAPS 2021 PHARMSCI 360 show from October 17-20th at the Pennsylvania Convention Center! Our booth will feature one of our most innovative, and advanced table-top fluid bed systems on the market, our SolidLab 1. Alongside the SolidLab 1, we will have some of our experts in the booth to answer any questions about our full OSD product portfolio, including …more

Introducing new North America Pharma Solid Business Development Manager Alex Trombley

Syntegon Pharma Technology is pleased to announce that Alex Trombley has joined our team as a Business Development and Process Specialist supporting our pharmaceutical oral solid dosage product line (Huettlin) in North America.

Alex graduated with a degree in Chemical Engineering from the University of Michigan. He has 5 years of experience in oral solid dosage formulation and process development with Eli Lilly. …more

BIOGRUND and Syntegon Partner to Make Your Life Easier

In many of my previous Syntegon articles, I have lamented the high cost of drug product development, with good reason. Developing an oral-solid-dose drug product is an expensive and risky endeavor, with formulation and process development being among the most significant and time consuming challenges.

It is no secret that formulation scientists face a host of hurdles when developing a formulation bound for tablet compression. First and foremost is achieving …more

Take your molecule to production

Compromise no longer; Syntegon’s GKF 60 R&D capsule filler is here! The GKF 60 combines a small machine footprint with the durability, innovation and flexibility you have grown to expect from Syntegon.  When designing the GKF 60, our mission was simple, “design it to do everything.” We think you will agree that it does exactly that.

In the OSD product development world there a few hard and fast rules; plans change; timelines shrink; and API is scarce. That is where the flexibility of the GKF 60 comes in. …more

Syntegon’s Slide Gate Technology Improves Capsule Filling Performance

Although Syntegon’s tamping-style capsule filling machines have set the standard for precision and durability in capsule filling for decades, that does not mean we rest on our laurels. At Syntegon, we tirelessly pursue innovations that make our industry leading equipment even better.  One of the most important of those innovations to come out of Syntegon’s Waiblingen, Germany facility in recent years is slide gate technology for capsule fillers. …more

Syntegon’s Pilot Scale High-Shear Mixer and Fluid Bed

Developing a pharmaceutical product within a Research and Development Lab can be a very expensive and time-consuming process for OSD manufacturers. Once a stable product has been developed within the lab setting, scaling up to pilot production can prove even more daunting for scientists. Pilot-scale machines provide pharmaceutical companies the tools to better understand a manufacturing process that was successful at lab scale, while also allowing for batches at less than production scale, where design changes can still be easily executed at less cost. Syntegon offers …more

Join Syntegon at the 2021 Virtual Pharma Expo

Join Syntegon at the 2021 Virtual Pharma Expo series event, focused on Oral Solid Dose Manufacturing. On Wednesday, May 5 at 9:30am EDT, Head of Pharma Service and Senior Scientist/Pharmacist Marc Michaelis will be presenting on Continuous Manufacturing. Learn about the benefits of moving from batch production to a continuous process.

Learn more about the event, and register for free here.

Automated Capsule Product Development comes to the US at Syntegon’s Partner, Parsolex

Developing an oral solid dosage (OSD) product is not easy; timelines are long, financial risks are considerable and challenges are many. Consequently, significant incentive exists to find efficiencies and streamline the product development process wherever possible. However, one aspect of the pharma development process remains unchanged. Regulatory agencies are unwavering in their demand for evidence that your manufacturing process is stable and the design space well defined; …more

Facing the Challenges of Low Fill-Weight Capsules

Developing and manufacturing hard-shell capsules with low fill-weights can be an especially challenging task. However, recent innovations provide the tools to make the job of manufacturing such products much easier, while also providing assurance that the capsules you make meet your stringent quality requirements. Whether you need to fill just API into capsules for clinical trials, need to manufacture a low-fill capsule product for dry powder inhalation, or simply have a product formulation that requires low fill-weight, the tools available today can make the job much simpler. …more

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